NPC-EXs Alleviate Endothelial Oxidative Stress and Dysfunction through the miR-210 Downstream Nox2 and VEGFR2 Pathways

Figure 4

Manipulation of miR-210 with inhibitor or mimic altered the effect of NPC-EXs on reducing Ang II-induced Nox2 expression. (a) Representative Western blot bands. (b) Summarized data showing the expression of Nox2 in ECs treated with different NPC-EXs; versus con; ⁺ versus vehicle; ^# versus NPC-EXs^con or NPC-EXs^sc; ^& versus NPC-EXs^anti-miR-210. EXs released from NPCs^con, NPCs^sc, NPC-EXs^anti-miR-210, or NPCs^miR-210 were denoted as NPC-EXs^con, NPC-EXs^sc, NPC-EXs^anti-miR-210, or NPC-EXs^miR-210. Data are expressed as mean ± SEM. /group.

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