|
| Process | Expression/activity of NOX | Effects/mechanism | Reference |
|
| Differentiation | ↑ NOX2 | Differentiation of stem cells/ROS-dependent Notch signaling pathway | [111] |
| ↓ NOX4 | Myogenesis, C2C12 differentiation/↓ ERK1/2 phosphorylation, MAP kinases | [112] |
↑ NOX2
↑ NOX4 | Cardiac precursor cells (CPCs) → ↑ c-kit(+) cells/unknown mechanism | [114] |
| ↑ NOX4 | Differentiation of endothelial cells into smooth muscle cells/TGFβ-1-dependent NOX4/H2O2 upregulation | [115] |
| ↑ NOX4 | NOX4/H2O2 dependent | [116–118] |
| (i) Neural crest stem cells (NCSCs) differentiation to neural cells |
| (ii) 2T3 preosteoblast differentiation |
| (iii) Renal progenitor cells differentiation to profibrotic cells |
| ↓ NOX4 | Neural crest stem cells (NCSCs) death or retarded growth of PNS | [116] |
|
| Stem cell self-renewal | ↑ NOX4 | Proliferation of neural stem cells/superoxide dependent | [122] |
| ↑ NOX3 | ↑ proliferation of mouse spermatogonial stem cells/unknown mechanism | [123] |
| ↓ NOX4 | ↓ proliferation and migration of adipose-derived stem cells (ADSCs)/↓ ERK1/2, Akt, ↓ PDGFβ1 | [124] |
| ↓ NOX | Proliferation of mesenchymal stem cells/↑ Nanog/Oct4 (TFs) | [125] |
NOX2
NOX4 | ↑ senescence of Ang. II-stimulated endothelial cells/unknown mechanism | [126] |
|
| Cancer stem cell growth and survival | NOX2 | ↑ proliferation of pancreatic cancer cells (SW1990 and BxPC-3)/NF-κB/STAT3 activation | [137] |
| ↑ NOX1 | ↑ enrichment of breast cancer stem-like cell population/RAS/Erk1/2/NOX1 activation | [138] |
| ↓ NOX2, NOX4, NOX5 | ↑ survival of prostate stem-like cells in vitro | [139] |
|
| Cancer stem cell drug resistance | ↑ NOX2 | ↑ resistance of patient-derived glioblastoma stem cells and chronic myeloid leukemia stem cells to tyrosine kinase inhibitors/NOX2/Egr1/Fyn upregulation | [143] |
|
