Protective Effects of Dinitrosyl Iron Complexes under Oxidative Stress in the Heart

Figure 7

Effects of Oxacom on reactive oxygen species accumulation in adult rat cardiomyocytes subjected to hypoxia-reoxygenation. Cardiomyocytes loaded with DHR-123 fluorescent indicator for ROS were sequentially perfused with normoxic and hypoxic buffers (indicated by arrows) and electrostimulated by rectangular pulses as 1 Hz. “Noisy” fragments of the curve correspond to electrostimulation and fluorescence recording periods. (a) Control cardiomyocytes. (b) Cardiomyocytes preincubated with 30 nM Oxacom. Typical recordings are shown.

(a)

(b)