Antihypertensive Effects of Roselle-Olive Combination in L-NAME-Induced Hypertensive Rats

Table 3

Effect of Roselle-Olive combination on ACE activity, NO, and oxidative status in the liver of L-NAME-induced hypertensive rats.

Groups	Liver homogenate
	ACE activity (ng/g)	NOx (μmol/l)	GSH (μmol/g)	MDA (nmol/g)
Group 1	1.9 ± 0.23^ǂ	74.8 ± 6.5^ǂ	7.4 ± 0.62^ǂ	85.7 ± 5.48^ǂ
Group 2	8.8 ± 0.29	47.6 ± 1.62	4.7 ± 0.23	126.7 ± 9.38
Group 3	1.3 ± 0.12^ǂ	83.7 ± 3.26^ǂ	6.4 ± 0.43	80.3 ± 4.01^ǂ
Group 4	1.3 ± 0.06^ǂ	67.7 ± 6.09^ǂ	6.6 ± 0.21^ǂ	82.8 ± 1.96^ǂ
Group 5	1.4 ± 0.04^ǂ	65.1 ± 4.94^ǂ	6.0 ± 0.22	86.2 ± 1.88^ǂ
Group 6	1.9 ± 0.05^ǂ	70.8 ± 2.72^ǂ	6.0 ± 0.64	82.2 ± 5.22^ǂ

Group 1: normal control; group 2: hypertensive control (L-NAME 50 mg/kg); group 3: L-NAME + lisinopril (10 mg/kg); group 4: L-NAME + Roselle-Olive (500 mg/kg); group 5: L-NAME + Roselle-Olive (250 mg/kg); group 6: L-NAME + Roselle-Olive (125 mg/kg). Values are expressed as mean ± SE (). , statistically significant from the normal control group at the corresponding time. , statistically significant from the hypertensive control group at the corresponding time.