Antihypertensive Effects of Roselle-Olive Combination in L-NAME-Induced Hypertensive Rats

Table 4

Effect of Roselle-Olive combination on ACE activity, NO, and oxidative status in the kidney of L-NAME-induced hypertensive rats.

Groups	Kidney homogenate
	ACE activity (ng/g)	NOx (μmol/l)	GSH (μmol/g)	MDA (nmol/g)
Group 1	2.0 ± 0.14^ǂ	121.1 ± 6.29^ǂ	8.1 ± 0.31^ǂ	78.4 ± 1.65^ǂ
Group 2	8.5 ± 0.23	51.5 ± 2.39	5.2 ± 0.38	108.8 ± 7.65
Group 3	1.4 ± 0.15^ǂ	121.8 ± 5.06^ǂ	6.6 ± 0.31^ǂ	90.7 ± 2.92
Group 4	1.4 ± 0.05^ǂ	62.6 ± 1.98	7.2 ± 0.29^ǂ	103.2 ± 3.65
Group 5	1.4 ± 0.04^ǂ	63.1 ± 2.93	7.2 ± 0.19^ǂ	100.0 ± 2.92
Group 6	1.9 ± 0.04^ǂ	78.0 ± 3.17^ǂ	7.1 ± 0.17^ǂ	100.7 ± 6.96

Group 1: normal control; group 2: hypertensive control (L-NAME 50 mg/kg); group 3: L-NAME + lisinopril (10 mg/kg); group 4: L-NAME + Roselle-Olive (500 mg/kg); group 5: L-NAME + Roselle-Olive (250 mg/kg); group 6: L-NAME + Roselle-Olive (125 mg/kg). Values are expressed as mean ± SE (). , statistically significant from the normal control group at the corresponding time. , statistically significant from the hypertensive control group at the corresponding time.