Activation of NLRP3 Inflammasome by Advanced Glycation End Products Promotes Pancreatic Islet Damage

Figure 5

Effects of NAC treatment on the abnormal response to glucose and islet β-cell apoptosis in mice administration of AGEs. C57BL/6J mice were injected intraperitoneally with BSA, AGEs, or AGEs plus the antioxidant NAC (40 mM in drinking water) for 6 weeks. GTT (a) and IRT (b) were performed after intraperitoneal injection of glucose (1.5 mg/g). per group. (c) Representative photomicrographs of TUNEL-positive cells in mice pancreatic sections. The positive control includes permeabilization of sections with deoxyribonuclease 1 to induce DNA strand breaks. Scale bar = 50 μm. (d) Histogram represents quantitative analysis of TUNEL-positive β cells per islet in each experimental group. per group. Values are expressed as mean ± SD, ^# versus BSA group. versus AGEs group.

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