Mitochondrial Respiration in Intact Peripheral Blood Mononuclear Cells and Sirtuin 3 Activity in Patients with Movement Disorders

Table 1

Mitochondrial respiration and sirtuin 3 (SIRT3) expression/activity in patients with movement disorders and in controls. Results are presented as mean ± standard deviation (ROUTINE, ROX) and median (interquartile range for LEAK, ETS, and SIRT3). All outcomes of mitochondrial respiration are measured in pmol O2/s10⁶ cells. SIRT3 protein expression is represented as μg/mg protein. SIRT3 activity is represented as U/μg protein.

	Controls	Patients with movement disorders
ROUTINE; (pmol O2/s10^6 cells)	19.3 ± 4.4	15.3 ± 4.5	0.0237
LEAK; (pmol O2/s10^6 cells)	6.02 5.37–6.78	4.2; 2.98–5.68	0.033
ETS; (pmol O2/s10^6 cells)	13.34 11.22–17.39	12.21 9.84–15.79	0.4168
ROX (pmol O2/s10^6 cells)	5.7 ± 1.6	4.2 ± 2.0	0.0486
SIRT3 expression; (μg/mg protein)	63.9 20.5–115.4	35.4 23.2–57.9	0.4309
SIRT3 activity; (U/μg protein)	181.17 60.9–344.6	71.40; 38.7–132.9	0.0178