Fish Scale Collagen Peptides Protect against CoCl₂/TNF-α-Induced Cytotoxicity and Inflammation via Inhibition of ROS, MAPK, and NF-κB Pathways in HaCaT Cells

Figure 6

Inhibitory effects of FSCP on TNF-α-induced activation of the MAPK signaling pathway. Treatment of HaCaT cells with FSCP did not significantly inhibit TNF-α-induced increase in p38/MAPK phosphorylation (a). Treatment of HaCaT cells with FSCP suppressed TNF-α-induced ERK (b) and JNK (c) activation. Results are presented as the means ± SD of three independent experiments. ^# versus the control and versus the TNF-α-treated group.

(a)

(b)

(c)