Increased Levels of Oxidative Stress Markers, Soluble CD40 Ligand, and Carotid Intima-Media Thickness Reflect Acceleration of Atherosclerosis in Male Patients with Ankylosing Spondylitis in Active Phase and without the Classical Cardiovascular Risk Factors

Table 2

Parameters of enzymatic antioxidant status (superoxide dismutase (SOD), its isoenzymes: manganese superoxide dismutase (SOD-Mn) and copper-zinc superoxide dismutase (SOD-CuZn), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) activity) and nonenzymatic antioxidant status (ferric reducing ability of plasma (FRAP), protein sulfhydryl (PSH), and uric acid (UA) concentration, as well as activity of ceruloplasmin (CER)) in ankylosing spondylitis (AS) patients and healthy subjects.

Parameter	AS patients ()	Healthy subjects ()
SOD (p) (NU/ml)	12.67 ± 1.98	10.93 ± 2.55	<0.001
SOD-Mn (p) (NU/ml)	5.08 ± 2.00	4.59 ± 1.88	0.223
SOD-CuZn (p) (NU/ml)	7.64 ± 2.31	6.79 ± 1.99	0.055
SOD (e) (NU/mgHb)	105.85 ± 22.60	95.50 ± 19.18	0.017
CAT (e) (IU/mgHb)	410.98 ± 63.56	352.55 ± 77.21	<0.001
GPx (e) (IU/gHb)	27.23 ± 6.43	24.49 ± 5.00	0.022
GR (e) (IU/gHb)	1.67 ± 0.58	1.38 ± 0.43	0.007
FRAP (p) (μmol/l)	550.38 ± 76.98	642.17 ± 105.67	<0.001
PSH (s) (μmol/l)	474.46 ± 192.06	559.07 ± 215.14	0.045
UA (s) (mg/dl)	4.73 ± 1.39	5.84 ± 1.53	<0.001

Values are expressed as means ± standard deviations (SD) of the means; p: plasma; s: serum; e: erythrocyte lysates.