Table of Contents Author Guidelines Submit a Manuscript
Oxidative Medicine and Cellular Longevity
Volume 2017, Article ID 9715898, 8 pages
https://doi.org/10.1155/2017/9715898
Research Article

Assessing Free-Radical-Mediated DNA Damage during Cardiac Surgery: 8-Oxo-7,8-dihydro-2′-deoxyguanosine as a Putative Biomarker

1Centro Cardiologico Monzino, IRCCS, Milan, Italy
2Dipartimento di Chirurgia Cardiaca, IRCCS Policlinico San Donato, Milan, Italy

Correspondence should be addressed to Benedetta Porro; ti.mfcc@orrop.attedeneb

Received 3 March 2017; Accepted 9 April 2017; Published 4 June 2017

Academic Editor: Michael Bukrinsky

Copyright © 2017 Linda Turnu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. M. Bravata, A. L. Gienger, K. M. McDonald et al., “Systematic review: the comparative effectiveness of percutaneous coronary interventions and coronary artery bypass graft surgery,” Annals of Internal Medicine, vol. 147, no. 10, pp. 703–716, 2007. View at Publisher · View at Google Scholar
  2. W. B. Gerritsen, L. P. Aarts, W. J. Morshuis, and F. J. Haas, “Indices of oxidative stress in urine of patients undergoing coronary artery bypass grafting,” European Journal of Clinical Chemistry and Clinical Biochemistry, vol. 35, no. 10, pp. 737–742, 1997. View at Google Scholar
  3. G. Lazzarino, P. Raatikainen, M. Nuutinen et al., “Myocardial release of malondialdehyde and purine compounds during coronary bypass surgery,” Circulation, vol. 90, no. 1, pp. 291–297, 1994. View at Publisher · View at Google Scholar
  4. V. Cavalca, E. Tremoli, B. Porro et al., “Oxidative stress and nitric oxide pathway in adult patients who are candidates for cardiac surgery: patterns and differences,” Interactive Cardiovascular and Thoracic Surgery, vol. 17, no. 6, pp. 923–930, 2013. View at Publisher · View at Google Scholar · View at Scopus
  5. J. Garcia-de-la-Asuncion, E. Pastor, J. Perez-Griera et al., “Oxidative stress injury after on-pump cardiac surgery: effects of aortic cross clamp time and type of surgery,” Redox Report, vol. 18, no. 5, pp. 193–199, 2013. View at Publisher · View at Google Scholar · View at Scopus
  6. V. Cavalca, E. Sisillo, F. Veglia et al., “Isoprostanes and oxidative stress in off-pump and on-pump coronary bypass surgery,” The Annals of Thoracic Surgery, vol. 81, no. 2, pp. 562–567, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. C. R. Luyten, F. J. van Overveld, L. A. De Backer et al., “Antioxidant defence during cardiopulmonary bypass surgery,” European Journal of Cardio-Thoracic Surgery, vol. 27, no. 4, pp. 611–616, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Vogt, A. Sattler, A. S. Sirat et al., “Different profile of antioxidative capacity results in pulmonary dysfunction and amplified inflammatory response after CABG surgery,” The Journal of Surgical Research, vol. 139, no. 1, pp. 136–142, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. B. Karahalil, E. Kesimci, E. Emerce, T. Gumus, and O. Kanbak, “The impact of OGG1, MTH1 and MnSOD gene polymorphisms on 8-hydroxy-2′-deoxyguanosine and cellular superoxide dismutase activity in myocardial ischemia-reperfusion,” Molecular Biology Reports, vol. 38, no. 4, pp. 2427–2435, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. B. van Loon, E. Markkanen, and U. Hubscher, “Oxygen as a friend and enemy: how to combat the mutational potential of 8-oxo-guanine,” DNA Repair, vol. 9, no. 6, pp. 604–616, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. T. P. Devasagayam, S. Steenken, M. S. Obendorf, W. A. Schulz, and H. Sies, “Formation of 8-hydroxy(deoxy)guanosine and generation of strand breaks at guanine residues in DNA by singlet oxygen,” Biochemistry, vol. 30, no. 25, pp. 6283–6289, 1991. View at Publisher · View at Google Scholar
  12. H. Kasai, “Analysis of a form of oxidative DNA damage, 8-hydroxy-2′-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis,” Mutation Research, vol. 387, no. 3, pp. 147–163, 1997. View at Publisher · View at Google Scholar · View at Scopus
  13. K. B. Beckman and B. N. Ames, “Oxidative decay of DNA,” The Journal of Biological Chemistry, vol. 272, no. 32, pp. 19633–19636, 1997. View at Publisher · View at Google Scholar · View at Scopus
  14. K. C. Cheng, D. S. Cahill, H. Kasai, S. Nishimura, and L. A. Loeb, “8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G–T and A–C substitutions,” The Journal of Biological Chemistry, vol. 267, no. 1, pp. 166–172, 1992. View at Google Scholar
  15. M. Serdar, E. Sertoglu, M. Uyanik et al., “Comparison of 8-hydroxy-2′-deoxyguanosine (8-oxodG) levels using mass spectrometer and urine albumin creatinine ratio as a predictor of development of diabetic nephropathy,” Free Radical Research, vol. 46, no. 10, pp. 1291–1295, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. K. Broedbaek, A. Weimann, E. S. Stovgaard, and H. E. Poulsen, “Urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine as a biomarker in type 2 diabetes,” Free Radical Biology & Medicine, vol. 51, no. 8, pp. 1473–1479, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Siomek, J. Tujakowski, D. Gackowski et al., “Severe oxidatively damaged DNA after cisplatin treatment of cancer patients,” International Journal of Cancer, vol. 119, no. 9, pp. 2228–2230, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Di Minno, L. Turnu, B. Porro et al., “8-Hydroxy-2-deoxyguanosine levels and heart failure: a systematic review and meta-analysis of the literature,” Nutrition, Metabolism, and Cardiovascular Diseases, vol. 27, no. 3, pp. 201–208, 2017. View at Publisher · View at Google Scholar
  19. A. Di Minno, L. Turnu, B. Porro et al., “8-Hydroxy-2-deoxyguanosine levels and cardiovascular disease: a systematic review and meta-analysis of the literature,” Antioxidants & Redox Signaling, vol. 24, no. 10, pp. 548–555, 2016. View at Publisher · View at Google Scholar · View at Scopus
  20. M. D. Evans, R. Olinski, S. Loft, and M. S. Cooke, “Toward consensus in the analysis of urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine as a noninvasive biomarker of oxidative stress,” FASEB Journal, vol. 24, no. 4, pp. 1249–1260, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. N. Delanty, M. P. Reilly, D. Pratico et al., “8-epi PGF2α generation during coronary reperfusion. A potential quantitative marker of oxidant stress in vivo,” Circulation, vol. 95, no. 11, pp. 2492–2499, 1997. View at Publisher · View at Google Scholar
  22. R. Andreoli, P. Manini, G. De Palma et al., “Quantitative determination of urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine, 8-oxo-7,8-dihydroguanine, 8-oxo-7,8-dihydroguanosine, and their non-oxidized forms: daily concentration profile in healthy volunteers,” Biomarkers, vol. 15, no. 3, pp. 221–231, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. M. B. Bogdanov, M. F. Beal, D. R. McCabe, R. M. Griffin, and W. R. Matson, “A carbon column-based liquid chromatography electrochemical approach to routine 8-hydroxy-2′-deoxyguanosine measurements in urine and other biologic matrices: a one-year evaluation of methods,” Free Radical Biology & Medicine, vol. 27, no. 5-6, pp. 647–666, 1999. View at Publisher · View at Google Scholar · View at Scopus
  24. V. Cavalca, F. Minardi, S. Scurati et al., “Simultaneous quantification of 8-iso-prostaglandin-F2α and 11-dehydro thromboxane B2 in human urine by liquid chromatography-tandem mass spectrometry,” Analytical Biochemistry, vol. 397, no. 2, pp. 168–174, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. U.D.o.H.a.H.S. Food and Drug Administration F and Center for Drug Evaluation and Research, Guidance for Industry: Bioanalytical Method Validation, 2013, http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm368107.pdf.
  26. B. K. Matuszewski, M. L. Constanzer, and C. M. Chavez-Eng, “Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS,” Analytical Chemistry, vol. 75, no. 13, pp. 3019–3030, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. L. Barregard, P. Moller, T. Henriksen et al., “Human and methodological sources of variability in the measurement of urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine,” Antioxidants & Redox Signaling, vol. 18, no. 18, pp. 2377–2391, 2013. View at Publisher · View at Google Scholar · View at Scopus
  28. C. W. Hu, M. T. Wu, M. R. Chao et al., “Comparison of analyses of urinary 8-hydroxy-2′-deoxyguanosine by isotope-dilution liquid chromatography with electrospray tandem mass spectrometry and by enzyme-linked immunosorbent assay,” Rapid Communications in Mass Spectrometry, vol. 18, no. 4, pp. 505–510, 2004. View at Publisher · View at Google Scholar
  29. P. Rossner Jr., V. Mistry, R. Singh, R. J. Sram, and M. S. Cooke, “Urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine values determined by a modified ELISA improves agreement with HPLC-MS/MS,” Biochemical and Biophysical Research Communications, vol. 440, no. 4, pp. 725–730, 2013. View at Publisher · View at Google Scholar · View at Scopus
  30. F. Xiang, X. Shuanglun, W. Jingfeng et al., “Association of serum 8-hydroxy-2′-deoxyguanosine levels with the presence and severity of coronary artery disease,” Coronary Artery Disease, vol. 22, no. 4, pp. 223–227, 2011. View at Publisher · View at Google Scholar · View at Scopus
  31. D. Gackowski, M. Kruszewski, A. Jawien, M. Ciecierski, and R. Olinski, “Further evidence that oxidative stress may be a risk factor responsible for the development of atherosclerosis,” Free Radical Biology & Medicine, vol. 31, no. 4, pp. 542–547, 2001. View at Publisher · View at Google Scholar · View at Scopus
  32. Y. Kaya, A. Cebi, N. Soylemez, H. Demir, H. H. Alp, and E. Bakan, “Correlations between oxidative DNA damage, oxidative stress and coenzyme Q10 in patients with coronary artery disease,” International Journal of Medical Sciences, vol. 9, no. 8, pp. 621–626, 2012. View at Publisher · View at Google Scholar · View at Scopus
  33. K. Arao, T. Yasu, T. Umemoto et al., “Effects of pitavastatin on fasting and postprandial endothelial function and blood rheology in patients with stable coronary artery disease,” Circulation Journal, vol. 73, no. 8, pp. 1523–1530, 2009. View at Publisher · View at Google Scholar · View at Scopus
  34. P. Jaruga, R. Rozalski, A. Jawien, A. Migdalski, R. Olinski, and M. Dizdaroglu, “DNA damage products (5'R)- and (5′S)-8,5′-cyclo-2′-deoxyadenosines as potential biomarkers in human urine for atherosclerosis,” Biochemistry, vol. 51, no. 9, pp. 1822–1824, 2012. View at Publisher · View at Google Scholar · View at Scopus
  35. W. Martinet, M. W. Knaapen, G. R. De Meyer, A. G. Herman, and M. M. Kockx, “Elevated levels of oxidative DNA damage and DNA repair enzymes in human atherosclerotic plaques,” Circulation, vol. 106, no. 8, pp. 927–932, 2002. View at Publisher · View at Google Scholar · View at Scopus
  36. N. Botto, S. Masetti, L. Petrozzi et al., “Elevated levels of oxidative DNA damage in patients with coronary artery disease,” Coronary Artery Disease, vol. 13, no. 5, pp. 269–274, 2002. View at Publisher · View at Google Scholar · View at Scopus
  37. C. Vassalle, L. Petrozzi, N. Botto, M. G. Andreassi, and G. C. Zucchelli, “Oxidative stress and its association with coronary artery disease and different atherogenic risk factors,” Journal of Internal Medicine, vol. 256, no. 4, pp. 308–315, 2004. View at Publisher · View at Google Scholar · View at Scopus
  38. L. G. Kevin, E. Novalija, and D. F. Stowe, “Reactive oxygen species as mediators of cardiac injury and protection: the relevance to anesthesia practice,” Anesthesia and Analgesia, vol. 101, no. 5, pp. 1275–1287, 2005. View at Publisher · View at Google Scholar · View at Scopus
  39. S. Basili, G. Tanzilli, E. Mangieri et al., “Intravenous ascorbic acid infusion improves myocardial perfusion grade during elective percutaneous coronary intervention: relationship with oxidative stress markers,” JACC Cardiovascular Interventions, vol. 3, no. 2, pp. 221–229, 2010. View at Publisher · View at Google Scholar · View at Scopus
  40. S. M. Harman, L. Liang, P. D. Tsitouras et al., “Urinary excretion of three nucleic acid oxidation adducts and isoprostane F2α measured by liquid chromatography-mass spectrometry in smokers, ex-smokers, and nonsmokers,” Free Radical Biology & Medicine, vol. 35, no. 10, pp. 1301–1309, 2003. View at Publisher · View at Google Scholar · View at Scopus
  41. Y. Yamano, S. Miyakawa, and T. Nakadate, “Association of arteriosclerosis index and oxidative stress markers in school children,” Pediatrics International, vol. 57, no. 3, pp. 449–454, 2015. View at Publisher · View at Google Scholar · View at Scopus
  42. T. England, E. Beatty, A. Rehman et al., “The steady-state levels of oxidative DNA damage and of lipid peroxidation (F2-isoprostanes) are not correlated in healthy human subjects,” Free Radical Research, vol. 32, no. 4, pp. 355–362, 2000. View at Publisher · View at Google Scholar
  43. T. M. Lee, T. F. Chou, and C. H. Tsai, “Association of pravastatin and left ventricular mass in hypercholesterolemic patients: role of 8-iso-prostaglandin F2α formation,” Journal of Cardiovascular Pharmacology, vol. 40, no. 6, pp. 868–874, 2002. View at Publisher · View at Google Scholar · View at Scopus
  44. R. Rodrigo, H. Prat, W. Passalacqua, J. Araya, C. Guichard, and J. P. Bachler, “Relationship between oxidative stress and essential hypertension,” Hypertension Research, vol. 30, no. 12, pp. 1159–1167, 2007. View at Publisher · View at Google Scholar · View at Scopus
  45. F. J. Lowe, E. O. Gregg, and M. McEwan, “Evaluation of biomarkers of exposure and potential harm in smokers, former smokers and never-smokers,” Clinical Chemistry and Laboratory Medicine, vol. 47, no. 3, pp. 311–320, 2009. View at Publisher · View at Google Scholar · View at Scopus
  46. E. Devangelio, F. Santilli, G. Formoso et al., “Soluble RAGE in type 2 diabetes: association with oxidative stress,” Free Radical Biology & Medicine, vol. 43, no. 4, pp. 511–518, 2007. View at Publisher · View at Google Scholar · View at Scopus