Assessing Free-Radical-Mediated DNA Damage during Cardiac Surgery: 8-Oxo-7,8-dihydro-2′-deoxyguanosine as a Putative Biomarker
Table 1
Overall population characteristics at baseline.
Variables
CAD ()
CTR ()
value
Demographic characteristics
Age, years
63.5 ± 9.7
58.5 ± 7.0
0.004
Male gender, number (%)
40 (76.9)
22 (55.0)
0.014
Clinical characteristics
Weight, kg
75.6 ± 13.8
78.1 ± 13.7
0.390
BMI, kg/m2
26 ± 5.2
27.5 ± 4.1
0.080
Active smokers, number (%)
6 (11.5)
6 (15)
0.630
Biochemical
Total cholesterol, mg/dL
190.7 ± 44.2
212.5 ± 29.0
0.004
LDL cholesterol, mg/dL
121.8 ± 35.6
139.5 ± 32.4
0.020
HDL cholesterol, mg/dL
48.0 ± 10.6
52.7 ± 12.9
0.004
Triglycerides, mg/dL
104.0 ± 41.6
130.3 ± 82.4
0.070
Fasting glycemia, mg/dL
117.7 ± 28.1
107.0 ± 31.3
0.190
Creatinine, mg/dL
149.9 ± 77.3
125.2 ± 51.8
0.070
Comorbidities
Diabetes, number (%)
7 (13.5)
1 (2.5)
0.080
Hypertension, number (%)
48 (92.3)
17 (42.5)
0.005
Hypercholesterolemia, number (%)
29 (55.8)
9 (22.5)
0.001
Obesity, number (%)
1 (1.9)
5 (12.5)
0.070
Medications
Aspirin, number (%)
33 (63.5)
0 (0)
Statins, number (%)
28 (53.9)
4 (10)
Oral hypoglycemics, number (%)
7 (13.5)
1 (2.5)
0.160
Antihypertensive, number (%)
48 (92.3)
13 (32.5)
Characteristics of the study groups: CAD patients () and CTR subjects (). Values are presented as mean ± SD or in absolute numbers (percentage of total).
