Oxidative Medicine and Cellular Longevity

Research Article

Spontaneous Production of Glutathione-Conjugated Forms of 1,2-Dichloropropane: Comparative Study on Metabolic Activation Processes of Dihaloalkanes Associated with Occupational Cholangiocarcinoma

Table 1

List of seven components picked up by differential analysis.


Halogenated hydrocarbon	ID	m/z (positive)	Retention time (min)	Formula	Theoretical m/z [M + H]⁺	GSTT1 (+) versus GSTT1(−)
Halogenated hydrocarbon	ID	m/z (positive)	Retention time (min)	Formula	Theoretical m/z [M + H]⁺	Ratio	value

1,2-DCP	#P2	364.1172	3.2	C13H21O7N3S	364.1173	1.15	0.036
	#P1	382.0835	8.3	C13H20O6N3SCl	382.0834	2.18	0.000
DCM	#M1	320.0911	2.4	C11H17O6N3S	320.0911	>10	0.032
	#M2	321.0944		Isotope peak of #M1		>10	0.031
	#M3	322.1068	3.0	C11H19O6N3S	322.1067	>10	0.005
	#M4	418.0680	0.9	C15H24ON3P5	418.0680	>10	0.008
	#M5	493.9794	0.9	C18H5O7N7P2	493.9798	>10	0.002

1,2-DCP: 1,2-dichloropropane; DCM: dichloromethane; GSTT1: glutathione S-transferase theta 1. Component IDs #P2 and #P1 correspond to the same ones in Figure 1(c), respectively. Ideal m/z as [M + H]⁺ in positive ion mode was calculated based on the monoisotopic mass of corresponding formula. Ratio and value were determined by using the SIEVE 2.1 program.