Figure 1: Diabetes aggravated the degree of MI/R injury in rats. The infarct size was detected by TTC staining (a). The levels of CK-MB and LDH release were determined by enzyme activity assay kits ((b) and (c)). The ultrastructural changes of rat hearts were detected by TEM (d): normal myofibrils (MF); normal mitochondria (MT); normal Z-lines (Z); disorganized myofibrils (△); swollen mitochondria (); expanded sarcoplasmic reticulum (←); disappearance of the Z-line (▶); and dissolved muscle cell membrane (←). Data are expressed as the mean ± SD. . versus sham; # and ## versus Ctrl + IR.