Apoptotic Protease Activating Factor-1 Inhibitor Mitigates Myocardial Ischemia Injury via Disturbing Procaspase-9 Recruitment by Apaf-1

<div>ZYZ-488 alleviated acute myocardial infarction injury. (a) Quantification of LDH, CK, and AST content in mice serum. (b) Infarct size of mice heart was determined by triphenyltetrazolium chloride (TTC) staining. (c) Histological analysis with H&amp;E staining on heart sections. Representative microphotography of H&amp;E stained sections from border zone in indicated groups. ZYZ-488-Low: myocardial infarction with ZYZ-488 (33.9 mg/kg); ZYZ-488-High: myocardial infarction with ZYZ-488 (67.8 mg/kg); LEO: myocardial infarction with LEO (43.2 mg/kg). 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Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: Apoptotic Protease Activating Factor-1 Inhibitor Mitigates Myocardial Ischemia Injury via Disturbing Procaspase-9 Recruitment by Apaf-1 