Apoptotic Protease Activating Factor-1 Inhibitor Mitigates Myocardial Ischemia Injury via Disturbing Procaspase-9 Recruitment by Apaf-1

Table 2

The physicochemical properties, ADMET predictions of compound. All descriptors are generated by the ADMET predictor software of Simulations Plus.

Property	Description	Recommended range	ZYZ-488	LEO
logP	Octanol-water partition coefficient	<4.5	−0.89	0.89
logD	Octanol-water distribution coefficient	<3.5	−0.89	−0.2
Peff	Human effective jejunal permeation in cm/s × 10^4	≥0.1	0.18	0.32
Sw	Aqueous solubility in mg/mL	≥0.010	11.4	6.06
Vd	Volume of distribution in L/kg	≤3.7	0.51	1.05
RBP	Blood-to-plasma concentration ratio	<1.0	0.81	0.89
Fup	Percent of drug unbound to plasma protein	>2%, <95%	41.86	38.23