Apoptotic Protease Activating Factor-1 Inhibitor Mitigates Myocardial Ischemia Injury via Disturbing Procaspase-9 Recruitment by Apaf-1

<table class="table-group" id="tab3"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td class="align_left">Compound</td><td class="align_center">ZYZ-488</td><td class="align_center" colspan="2">LEO</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td class="align_left">Phase I</td><td class="align_center">N</td><td class="align_center">CYP3A4</td><td class="align_center">Cl<sub>int</sub> (<i>μ</i>L/min/mg) = 0.246</td></tr><tr><td class="align_left">Phase II</td><td class="align_center">N</td><td class="align_center">UGT1A1, UGT2B7</td><td class="align_left"> </td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Prediction of various isoforms of phase I and phase II metabolism enzyme.

Oxidative Medicine and Cellular Longevity

tab3

Table 3

Table 3: Apoptotic Protease Activating Factor-1 Inhibitor Mitigates Myocardial Ischemia Injury via Disturbing Procaspase-9 Recruitment by Apaf-1 