Treatment Effects of Ischemic Stroke by Berberine, Baicalin, and Jasminoidin from Huang-Lian-Jie-Du-Decoction (HLJDD) Explored by an Integrated Metabolomics Approach

Figure 2

Neurological deficit, ischemic infarct, and histopathological assessment. (a) Mortality, infarct volume examinations, and neurobehavioral scores. (b) TTC sting of brains (). (c) Histopathological examination of brain tissues by hematoxylin-eosin (H&E) staining (×400 magnification; ): neuronal loss and presence of numerous vacuolated spaces (black arrow) and disordered neuron arrangement (red arrow). (d) The abnormal neurons were counted and expressed relatively to the sham group ( in each group). ^## and ^###, MCAO group versus sham group; , , and , drug-treated groups versus MCAO group.

(a)

(b)

(c)

(d)