Treatment Effects of Ischemic Stroke by Berberine, Baicalin, and Jasminoidin from Huang-Lian-Jie-Du-Decoction (HLJDD) Explored by an Integrated Metabolomics Approach

Figure 6

Correlation network of differential metabolites in serum of all groups. Only correlations with absolute values of correlation coefficients greater than 0.65 and values <0.05 were kept. The nodes represent the metabolites, and the lines between the nodes indicate the biological relationships between the two corresponding metabolites. The red (blue) metabolites represent the upregulated metabolites (the downregulated metabolites) in MCAO rats compared with the sham rats or in drug-treated rats compared with the MCAO rats. The solid lines between the molecules indicate a correlation between the molecules; the line colors of red and blue display positive and negative relationships, respectively. Metabolites of similar structures were connected by the dotted lines, indicating a possible biochemical reaction between the molecules.