Treatment Effects of Ischemic Stroke by Berberine, Baicalin, and Jasminoidin from Huang-Lian-Jie-Du-Decoction (HLJDD) Explored by an Integrated Metabolomics Approach

Figure 9

Effects of HLJDD and its three principal components on autophagy. (a) The protein levels of p-PI3K, p-AKT, and p-GSK-3β in brains treated with HLJDD and its three principals (). (b) The protein levels of LC3-I, LC3-II, and p62 in brains treated with HLJDD and its three principals (). (c) The protein levels of p-mTOR, beclin1, Atg-3, Atg-5, Atg-7, and Atg-12 in brains treated with HLJDD and its three principals (). Results of quantitative analysis values are expressed as mean ± SD (). ^#, ^##, and ^###, MCAO group versus sham group; , , and , drug-treated groups versus MCAO group.

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