Coenzyme Q10 Regulates Antioxidative Stress and Autophagy in Acute Myocardial Ischemia-Reperfusion Injury
Table 2
The change of cardiac function.
AMI/R
CQ10 + AMI/R
Sham
2 h
24 h
72 h
Sham
2 h
24 h
72 h
HR (bpm)
395.26 ± 35.78
396.14 ± 42.74
402.20 ± 42.12
418.54 ± 39.56
412.70 ± 39.34
397.24 ± 36.24
409.20 ± 38.92
392.87 ± 42.13
IVSd (mm)
1.64 ± 0.27
1.58 ± 0.34
1.62 ± 0.31
1.61 ± 0.32
1.64 ± 0.34
1.72 ± 0.28
1.65 ± 0.41
1.68 ± 0.39
IVS (mm)
2.56 ± 0.37
2.30 ± 0.44
2.55 ± 0.81
2.49 ± 0.44
2.67 ± 0.13
2.47 ± 0.58
2.55 ± 0.18
2.43 ± 0.21
LVIDd (mm)
4.11 ± 0.94
4.18 ± 1.48
4.15 ± 0.67
4.21 ± 0.67
4.15 ± 0.19
3.97 ± 0.16
4.05 ± 0.45
4.14 ± 0.42
LVID (mm)
2.45 ± 0.57
2.50 ± 0.95
2.53 ± 0.79
2.43 ± 0.89
2.53 ± 0.18
2.57 ± 0.12
2.45 ± 0.27
2.49 ± 0.38
SV (cm3)
0.25 ± 0.08
0.24 ± 0.05
0.23 ± 0.04
0.23 ± 0.06
0.22 ± 0.07
0.24 ± 0.06
0.20 ± 0.08
0.23 ± 0.10
FS (%)
53.17 ± 5.76
54.74 ± 1.87
55.45 ± 9.63
52.37 ± 4.13
52.12 ± 4.82
50.13 ± 2.07
54.17 ± 7.88
51.21 ± 4.37
EF (%)
93.25 ± 3.14
80.23 ± 7.12
70.26 ± 5.26
59.12 ± 5.81
92.14 ± 2.65
85.42 ± 5.27
79.56 ± 5.36
67.12 ± 6.18
LVSP (mmHg)
84.25 ± 12.85
74.67 ± 10.15
65.84 ± 9.84
61.84 ± 10.04
84.42 ± 12.55
79.45 ± 10.25
71.44 ± 14.13
67.82 ± 13.32
LVEDP (mmHg)
2.16 ± 0.09
2.53 ± 0.08
2.86 ± 0.12
3.42 ± 0.07
2.19 ± 0.14
2.33 ± 0.09
2.64 ± 0.17
2.97 ± 0.15
+dp/dtmax (mmHg/ms)
3.79 ± 0.12
3.37 ± 0.06
2.18 ± 0.07
1.84 ± 0.08
3.80 ± 0.08
3.49 ± 0.06
2.88 ± 0.09
2.25 ± 0.12
−dp/dtmax (mmHg/ms)
3.02 ± 0.06
2.56 ± 0.48
2.37 ± 0.54
1.57 ± 0.54
2.92 ± 0.08
2.75 ± 0.04
2.49 ± 0.09
1.89 ± 0.09
CQ10 improved cardiac function but did not change cardiac structure in rats with acute myocardial ischemia-reperfusion injury at same time point. IVSd: diastolic interventricular septal wall thickness; IVS: systole inter-ventricular septal wall thickness; LVIDd: diastolic left ventricular internal dimension; LVID: systole left ventricular internal dimension; EF: left ventricular ejection fraction; SV: systole volume; FS: left ventricular fractional shortening; LVSP: left ventricular systolic pressure; LVEDP: left ventricular end-diastolic pressure; +dp/dtmax: the maximum change rate of left ventricular pressure rise; −dp/dtmax: the maximum change rate of left ventricular pressure fall; AMI/R: acute myocardial ischemia/reperfusion. was considered statistically significant; .
