Vialinin A, an Edible Mushroom-Derived p-Terphenyl Antioxidant, Prevents VEGF-Induced Neovascularization In Vitro and In Vivo

Figure 2

Effect of vialinin A on VEGF-induced migration in HUVEC. Growth-arrested HUVECs were pretreated with vialinin A (5 μM) followed by treatment with VEGF (10 ng/mL) for 18 h. Wound scratch assay to determine cell migration was performed as described in Materials and Methods. (a) Microscopic images were taken at 0 h and 18 h showing VEGF-induced migration in HUVEC in the presence or absence of vialinin A. Scale bar = 400 μm. (b) Bars showing the quantification of migration (%) as described in Materials and Methods. Representative images from three independent experiments are shown. Values are the mean ± SD (). when compared to untreated control; ^## when compared to VEGF treated.

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