Vialinin A, an Edible Mushroom-Derived p-Terphenyl Antioxidant, Prevents VEGF-Induced Neovascularization In Vitro and In Vivo

Figure 6

Effect of vialinin A on angiogenesis in vivo. Matrigel plugs containing vialinin A (5 μM) ± VEGF (10 ng/mL) were inserted in dorsal flanks of C57BL/6J mouse. After 10 days, Matrigel plugs were dissected out, sectioned, and stained with various endothelial markers. Matrigel plug sections were stained with (a) hematoxylin and eosin, (b) Masson’s trichrome, (c) CD31, and (d) von Willebrand factor (vWF). Representative images are shown ().