Changes of KEAP1/NRF2 and IKB/NF-κB Expression Levels Induced by Cell-Free DNA in Different Cell Types

Figure 2

NFKB1 and NRF2 expression curves under the action of (a) GC-rich and (b) oxidized fragments in mesenchymal stem cells (MSC). The expression levels were determined every 5 minutes after adding the corresponding fragments (model GC-rich fragments, model oxidized fragments) using real-time PCR. For each gene, the expression level was calculated relating to the internal standard gene ТВР, with a spread in values at every point not exceeding 5%. Significant difference () between the relative values of NRF2 and NFKB1.

(a)

(b)