Intermittent Hypoxia Increases the Severity of Bleomycin-Induced Lung Injury in Mice

Figure 4

Intermittent hypoxia and bleomycin enhanced lung nitrosative/oxidative stress in mouse lungs. (a) 3-nitrotyrosine presence was assessed by immunostaining on lung sections of mice prepared at day 4 in the 4 experimental groups. The figure is representative of at least 5 individual mice for each group. Magnification ×200. (b) 8-OH-DG concentration was assessed by ELISA in lung homogenate of mice at day 4 in the 4 experimental groups. Data represent means ± SE, n = 4-5 mice per group.

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