Table of Contents Author Guidelines Submit a Manuscript
Oxidative Medicine and Cellular Longevity
Volume 2018, Article ID 1240192, 13 pages
https://doi.org/10.1155/2018/1240192
Research Article

Intermittent Hypoxia Increases the Severity of Bleomycin-Induced Lung Injury in Mice

1Laboratoire Hypoxie & Poumon (EA 2363), Université Paris 13, Sorbonne Paris Cité, 93017 Bobigny, France
2Hôpital Avicenne (AP-HP), 93009 Bobigny, France
3AP-HP, Hôpital Jean Verdier, 93140 Bondy, France
4UPMC, Sorbonne Université, 75013 Paris, France

Correspondence should be addressed to Carole Planès; rf.phpa@senalp.elorac

Received 26 July 2017; Revised 3 January 2018; Accepted 10 January 2018; Published 14 March 2018

Academic Editor: Jean-Louis Pepin

Copyright © 2018 Thomas Gille et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. T. Gille, M. Didier, M. Boubaya et al., “Obstructive sleep apnoea and related comorbidities in incident idiopathic pulmonary fibrosis,” The European Respiratory Journal, vol. 49, no. 6, article 1601934, 2017. View at Publisher · View at Google Scholar
  2. L. H. Lancaster, W. R. Mason, J. A. Parnell et al., “Obstructive sleep apnea is common in idiopathic pulmonary fibrosis,” Chest, vol. 136, no. 3, pp. 772–778, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. C. Mermigkis, J. Chapman, J. Golish et al., “Sleep-related breathing disorders in patients with idiopathic pulmonary fibrosis,” Lung, vol. 185, no. 3, pp. 173–178, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. G. Milioli, M. Bosi, V. Poletti et al., “Sleep and respiratory sleep disorders in idiopathic pulmonary fibrosis,” Sleep Medicine Reviews, vol. 26, pp. 57–63, 2016. View at Publisher · View at Google Scholar · View at Scopus
  5. T. E. King Jr, A. Pardo, and M. Selman, “Idiopathic pulmonary fibrosis,” Lancet, vol. 378, no. 9807, pp. 1949–1961, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. B. Ley, H. R. Collard, and T. E. King Jr., “Clinical course and prediction of survival in idiopathic pulmonary fibrosis,” American Journal of Respiratory and Critical Care Medicine, vol. 183, no. 4, pp. 431–440, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. G. Raghu, “The role of gastroesophageal reflux in idiopathic pulmonary fibrosis,” The American Journal of Medicine, vol. 115, Supplement 1, no. 3, pp. 60–64, 2003. View at Publisher · View at Google Scholar · View at Scopus
  8. V. L. Kinnula, C. L. Fattman, R. J. Tan, and T. D. Oury, “Oxidative stress in pulmonary fibrosis: a possible role for redox modulatory therapy,” American Journal of Respiratory and Critical Care Medicine, vol. 172, no. 4, pp. 417–422, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. D. M. Walters, H. Y. Cho, and S. R. Kleeberger, “Oxidative stress and antioxidants in the pathogenesis of pulmonary fibrosis: a potential role for Nrf2,” Antioxidants & Redox Signaling, vol. 10, no. 2, pp. 321–332, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. I. Almendros, Y. Wang, and D. Gozal, “The polymorphic and contradictory aspects of intermittent hypoxia,” American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 307, no. 2, pp. L129–L140, 2014. View at Publisher · View at Google Scholar · View at Scopus
  11. L. Lavie, “Oxidative stress in obstructive sleep apnea and intermittent hypoxia – revisited – the bad ugly and good: implications to the heart and brain,” Sleep Medicine Reviews, vol. 20, pp. 27–45, 2015. View at Publisher · View at Google Scholar · View at Scopus
  12. P. Levy, M. Kohler, M. N. WT et al., “Obstructive sleep apnoea syndrome,” Nature Reviews Disease Primers, vol. 1, article 15015, 2015. View at Publisher · View at Google Scholar · View at Scopus
  13. V. Pialoux, P. J. Hanly, G. E. Foster et al., “Effects of exposure to intermittent hypoxia on oxidative stress and acute hypoxic ventilatory response in humans,” American Journal of Respiratory and Critical Care Medicine, vol. 180, no. 10, pp. 1002–1009, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. B. B. Moore and C. M. Hogaboam, “Murine models of pulmonary fibrosis,” American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 294, no. 2, pp. L152–L160, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. M. A. Mouratis and V. Aidinis, “Modeling pulmonary fibrosis with bleomycin,” Current Opinion in Pulmonary Medicine, vol. 17, no. 5, pp. 355–361, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. N. Randrianarison, C. Clerici, C. Ferreira et al., “Low expression of the β-ENaC subunit impairs lung fluid clearance in the mouse,” American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 294, no. 3, pp. L409–L416, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. C. Planes, N. H. Randrianarison, R. P. Charles et al., “ENaC‐mediated alveolar fluid clearance and lung fluid balance depend on the channel‐activating protease 1,” EMBO Molecular Medicine, vol. 2, no. 1, pp. 26–37, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. J. Zhou, L. Ge, C. Jia et al., “ROS-mediated different homeostasis of murine corneal epithelial progenitor cell line under oxidative stress,” Scientific Reports, vol. 6, no. 1, p. 36481, 2016. View at Publisher · View at Google Scholar · View at Scopus
  19. C. M. Simbulan-Rosenthal, D. S. Rosenthal, S. Iyer, A. H. Boulares, and M. E. Smulson, “Transient poly(ADP-ribosyl)ation of nuclear proteins and role of poly(ADP-ribose) polymerase in the early stages of apoptosis,” The Journal of Biological Chemistry, vol. 273, no. 22, pp. 13703–13712, 1998. View at Publisher · View at Google Scholar · View at Scopus
  20. P. Levy, J. L. Pepin, C. Arnaud et al., “Intermittent hypoxia and sleep-disordered breathing: current concepts and perspectives,” The European Respiratory Journal, vol. 32, no. 4, pp. 1082–1095, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. B. C. Willis, J. M. Liebler, K. Luby-Phelps et al., “Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-β1,” The American Journal of Pathology, vol. 166, no. 5, pp. 1321–1332, 2005. View at Publisher · View at Google Scholar
  22. Y. Uzunhan, O. Bernard, D. Marchant et al., “Mesenchymal stem cells protect from hypoxia-induced alveolar epithelial-mesenchymal transition,” American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 310, no. 5, pp. L439–L451, 2016. View at Publisher · View at Google Scholar · View at Scopus
  23. L. B. Ware and M. A. Matthay, “The acute respiratory distress syndrome,” The New England Journal of Medicine, vol. 342, no. 18, pp. 1334–1349, 2000. View at Publisher · View at Google Scholar · View at Scopus
  24. E. Hummler and C. Planes, “Importance of ENaC-mediated sodium transport in alveolar fluid clearance using genetically-engineered mice,” Cellular Physiology and Biochemistry, vol. 25, no. 001, pp. 063–070, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. M. A. Matthay, “Resolution of pulmonary edema. Thirty years of progress,” American Journal of Respiratory and Critical Care Medicine, vol. 189, no. 11, pp. 1301–1308, 2014. View at Publisher · View at Google Scholar · View at Scopus
  26. T. Gille, N. Randrianarison-Pellan, A. Goolaerts et al., “Hypoxia-induced inhibition of epithelial Na+ channels in the lung. Role of Nedd4-2 and the ubiquitin-proteasome pathway,” American Journal of Respiratory Cell and Molecular Biology, vol. 50, no. 3, pp. 526–537, 2014. View at Publisher · View at Google Scholar · View at Scopus
  27. S. Matalon, R. Bartoszewski, and J. F. Collawn, “Role of epithelial sodium channels in the regulation of lung fluid homeostasis,” American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 309, no. 11, pp. L1229–L1238, 2015. View at Publisher · View at Google Scholar · View at Scopus
  28. C. Planes, M. Blot-Chabaud, M. A. Matthay, S. Couette, T. Uchida, and C. Clerici, “Hypoxia and β2-agonists regulate cell surface expression of the epithelial sodium channel in native alveolar epithelial cells,” The Journal of Biological Chemistry, vol. 277, no. 49, pp. 47318–47324, 2002. View at Publisher · View at Google Scholar · View at Scopus
  29. S. I. Hagiwara, Y. Ishii, and S. Kitamura, “Aerosolized administration of N-acetylcysteine attenuates lung fibrosis induced by bleomycin in mice,” American Journal of Respiratory and Critical Care Medicine, vol. 162, no. 1, pp. 225–231, 2000. View at Publisher · View at Google Scholar · View at Scopus
  30. C. Li, M. M. Wright, and R. M. Jackson, “Reactive species mediated injury of human lung epithelial cells after hypoxia-reoxygenation,” Experimental Lung Research, vol. 28, no. 5, pp. 373–389, 2002. View at Publisher · View at Google Scholar · View at Scopus
  31. W. Xu, L. Chi, B. W. Row et al., “Increased oxidative stress is associated with chronic intermittent hypoxia-mediated brain cortical neuronal cell apoptosis in a mouse model of sleep apnea,” Neuroscience, vol. 126, no. 2, pp. 313–323, 2004. View at Publisher · View at Google Scholar · View at Scopus
  32. J. Xu, Y. S. Long, D. Gozal, and P. N. Epstein, “β-cell death and proliferation after intermittent hypoxia: role of oxidative stress,” Free Radical Biology and Medicine, vol. 46, no. 6, pp. 783–790, 2009. View at Publisher · View at Google Scholar · View at Scopus
  33. D. Bouvry, C. Planès, L. Malbert-Colas, V. Escabasse, and C. Clerici, “Hypoxia-induced cytoskeleton disruption in alveolar epithelial cells,” American Journal of Respiratory Cell and Molecular Biology, vol. 35, no. 5, pp. 519–527, 2006. View at Publisher · View at Google Scholar · View at Scopus
  34. S. Krick, B. G. Eul, J. Hänze et al., “Role of hypoxia-inducible factor-1α in hypoxia-induced apoptosis of primary alveolar epithelial type II cells,” American Journal of Respiratory Cell and Molecular Biology, vol. 32, no. 5, pp. 395–403, 2005. View at Publisher · View at Google Scholar · View at Scopus
  35. Y. Tagawa, N. Hiramatsu, A. Kasai et al., “Induction of apoptosis by cigarette smoke via ROS-dependent endoplasmic reticulum stress and CCAAT/enhancer-binding protein-homologous protein (CHOP),” Free Radical Biology and Medicine, vol. 45, no. 1, pp. 50–59, 2008. View at Publisher · View at Google Scholar · View at Scopus
  36. R. K. Braun, O. Broytman, F. M. Braun et al., “Chronic intermittent hypoxia worsens bleomycin-induced lung fibrosis in rats,” Respiratory Physiology & Neurobiology, 2017. View at Publisher · View at Google Scholar · View at Scopus