Losartan Ameliorates Calcium Oxalate-Induced Elevation of Stone-Related Proteins in Renal Tubular Cells by Inhibiting NADPH Oxidase and Oxidative Stress

Figure 1

Effects of Ang II and COM on ROS generation in NRK-52E cells. (a) Cells were treated with various Ang II (0.1, 1, 10, 100, and 1000 nM) for 6 h, and then intracellular ROS was detected by flow cytometry. (b) Cells were treated with various COM (0, 0.1, 0.5, 1, 5, and 10 mM) for 6 h, and then intracellular ROS was detected by flow cytometry. (c) Cells were treated with COM (1 mM) for 0, 3, 6, 12, 24, and 48 h, and then intracellular ROS was detected by flow cytometry. The data are expressed as mean ± SEM. compared with the control group.

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