Losartan Ameliorates Calcium Oxalate-Induced Elevation of Stone-Related Proteins in Renal Tubular Cells by Inhibiting NADPH Oxidase and Oxidative Stress

Figure 2

Ang II/AT1R expression was increased during exposure to CaOx crystals which was alleviated by losartan. NRK-52E cells were cultivated with COM (1 mM) for 6 h; the expression of AT1R was increased at both mRNA (a) and protein (b) levels. compared with the Ang II group. (c) The serum concentration of Ang II was increased in the hyperoxaluria group compared with the untreated control group which was alleviated by losartan administration. (d) AT1R expression of the hyperoxaluria group was upregulated compared with the untreated control group which was also alleviated by losartan administration, as determined by Western blotting. The data are expressed as mean ± SEM. compared with the control group and compared with the hyperoxaluria group.

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