Resveratrol Inhibits ROS-Promoted Activation and Glycolysis of Pancreatic Stellate Cells via Suppression of miR-21

<div>RSV impedes H<sub>2</sub>O<sub>2</sub>-driven ROS-induced glycolysis in PSCs. (a, b) PSCs were treated in groups as indicated, and ROS were detected using DCFH-DA probes. Representative flow cytometric images and the mean fluorescence intensity (MFI) of each group are shown. (c, d) PSCs from indicated groups were extracted to detect Glut1, HK2, PKM2, and LDHA levels by Western blot, (e) and the culture media (CM) were collected to measure lactate production. Lactate production was normalized by the concentration of protein in each group. 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Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: Resveratrol Inhibits ROS-Promoted Activation and Glycolysis of Pancreatic Stellate Cells via Suppression of miR-21 