Bach1: Function, Regulation, and Involvement in Disease

Figure 2

Model for competition between Nrf2 and Bach1 on MARE of HO-1 in response to oxidative stimuli. During oxidative stress, Nrf2 dissociates from Keap1 and Nrf2 degradation is inhibited, so Nrf2 will accumulate in the cytoplasm and translocate into the nucleus. Then, Nrf2 binds to MAREs as a heterodimer with small Mafs, activating HO-1 expression, while Bach1 is displaced from MAREs and exported out of the nucleus.