Bach1: Function, Regulation, and Involvement in Disease

Figure 4

Model for genes regulated by Bach1 in cancer cells. Bach1-Maf heterodimer recruits both CHD8 and DNMT3B, leading to the hypermethylation and transcriptional silencing of tumor-suppressor genes (CIMP and HIM). Meanwhile, Bach1-Maf can increase the expression of MMP1, CXCR4, and vimentin, contributing to cancer metastasis and invasion.