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Oxidative Medicine and Cellular Longevity
Volume 2018 (2018), Article ID 1364165, 9 pages
https://doi.org/10.1155/2018/1364165
Research Article

PKM2 Is Required to Activate Myeloid Dendritic Cells from Patients with Severe Aplastic Anemia

1The Department of Hematology, General Hospital of Tianjin Medical University, Tianjin, China
2The Department of Hematology, The Second Hospital of Tianjin Medical University, Tianjin, China

Correspondence should be addressed to Zonghong Shao; nc.ude.umt@gnohgnozoahs

Received 26 September 2017; Revised 22 December 2017; Accepted 10 January 2018; Published 15 February 2018

Academic Editor: Massimo Collino

Copyright © 2018 Chunyan Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. Yamazaki, “Acquired aplastic anemia,” Rinshō Ketsueki, vol. 57, no. 2, pp. 91–97, 2016. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Miano and C. Dufour, “The diagnosis and treatment of aplastic anemia: a review,” International Journal of Hematology, vol. 101, no. 6, pp. 527–535, 2015. View at Publisher · View at Google Scholar · View at Scopus
  3. S. Zonghong, T. Meifeng, W. Huaquan et al., “Circulating myeloid dendritic cells are increased in individuals with severe aplastic anemia,” International Journal of Hematology, vol. 93, no. 2, pp. 156–162, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. W. Yang, Y. Xia, D. Hawke et al., “PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis,” Cell, vol. 150, no. 4, pp. 685–696, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. B. Chaneton and E. Gottlieb, “Rocking cell metabolism: revised functions of the key glycolytic regulator PKM2 in cancer,” Trends in Biochemical Sciences, vol. 37, no. 8, pp. 309–316, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. J. C. Alves-Filho and E. M. Palsson-McDermott, “Pyruvate kinase M2: a potential target for regulating inflammation,” Frontiers in Immunology, vol. 7, p. 145, 2016. View at Publisher · View at Google Scholar · View at Scopus
  7. W. Yang and Z. Lu, “Pyruvate kinase M2 at a glance,” Journal of Cell Science, vol. 128, no. 9, pp. 1655–1660, 2015. View at Publisher · View at Google Scholar · View at Scopus
  8. X. Wu, Y. Zhou, K. Zhang, Q. Liu, and D. Guo, “Isoform-specific interaction of pyruvate kinase with hepatitis C virus NS5B,” FEBS Letters, vol. 582, no. 15, pp. 2155–2160, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Sen, S. L. Deshmane, R. Kaminski, S. Amini, and P. K. Datta, “Non-metabolic role of PKM2 in regulation of the HIV-1 LTR,” Journal of Cellular Physiology, vol. 232, no. 3, pp. 517–525, 2017. View at Publisher · View at Google Scholar · View at Scopus
  10. J. M. Williams, G. C. Chen, L. Zhu, and R. F. Rest, “Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth,” Molecular Microbiology, vol. 27, no. 1, pp. 171–186, 1998. View at Publisher · View at Google Scholar · View at Scopus
  11. Z. Zhang, Q. Liu, Y. Che et al., “Antigen presentation by dendritic cells in tumors is disrupted by altered metabolism that involves pyruvate kinase M2 and its interaction with SOCS3,” Cancer Research, vol. 70, no. 1, pp. 89–98, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. Y. Zeng and E. Katsanis, “The complex pathophysiology of acquired aplastic anaemia,” Clinical and Experimental Immunology, vol. 180, no. 3, pp. 361–370, 2015. View at Publisher · View at Google Scholar · View at Scopus
  13. Red Blood Cell Disease (Anemia) Group, Chinese Society of Hematology, Chinese Medical Association, “Chinese expert consensus on the diagnosis and treatment of aplastic anemia (2017),” Zhonghua Xue Ye Xue Za Zhi, vol. 38, pp. 1–5, 2017. View at Publisher · View at Google Scholar
  14. E. M. Palsson-McDermott and L. A. O'Neill, “The Warburg effect then and now: from cancer to inflammatory diseases,” BioEssays, vol. 35, no. 11, pp. 965–973, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Schurich, L. J. Pallett, D. Jajbhay et al., “Distinct metabolic requirements of exhausted and functional virus-specific CD8 T cells in the same host,” Cell Reports, vol. 16, no. 5, pp. 1243–1252, 2016. View at Publisher · View at Google Scholar · View at Scopus
  16. M. P. Keppel and M. A. Cooper, “Assessment of NK cell metabolism,” Methods in Molecular Biology, vol. 1441, pp. 27–42, 2016. View at Publisher · View at Google Scholar · View at Scopus
  17. E. M. Palsson-McDermott, A. M. Curtis, G. Goel et al., “Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages,” Cell Metabolism, vol. 21, no. 1, pp. 65–80, 2015. View at Publisher · View at Google Scholar · View at Scopus
  18. Z. Liu and P. A. Roche, “Macropinocytosis in phagocytes: regulation of MHC class-II-restricted antigen presentation in dendritic cells,” Frontiers in Physiology, vol. 6, p. 1, 2015. View at Publisher · View at Google Scholar · View at Scopus
  19. C. Arnold-Schrauf, L. Berod, and T. Sparwasser, “Dendritic cell specific targeting of MyD88 signalling pathways in vivo,” European Journal of Immunology, vol. 45, no. 1, pp. 32–39, 2015. View at Publisher · View at Google Scholar · View at Scopus
  20. E. C. de Jong, H. H. Smits, and M. L. Kapsenberg, “Dendritic cell-mediated T cell polarization,” Springer Seminars in Immunopathology, vol. 26, no. 3, pp. 289–307, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. J. Dieker, J. Tel, E. Pieterse et al., “Circulating apoptotic microparticles in systemic lupus erythematosus patients drive the activation of dendritic cell subsets and prime neutrophils for NETosis,” Arthritis & Rhematology, vol. 68, no. 2, pp. 462–472, 2016. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Saeidi, M. Buggert, K. F. Che et al., “Regulation of CD8+ T-cell cytotoxicity in HIV-1 infection,” Cellular Immunology, vol. 298, no. 1-2, pp. 126–133, 2015. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Salou, A. Garcia, L. Michel et al., “Expanded CD8 T-cell sharing between periphery and CNS in multiple sclerosis,” Annals of Clinical Translational Neurology, vol. 2, no. 6, pp. 609–622, 2015. View at Publisher · View at Google Scholar