Carnosic Acid, a Natural Diterpene, Attenuates Arsenic-Induced Hepatotoxicity via Reducing Oxidative Stress, MAPK Activation, and Apoptotic Cell Death Pathway

Figure 7

The effect on ROS accumulation, lipid peroxidation, protein carbonylation, and endogenous redox systems in the absence (NaAsO₂) and presence of CA (NaAsO₂ + CA) in vivo in the liver of experimental mice. Values are represented as mean ± SD (). ^#Values significantly () differ from normal control. ^#Values significantly () differ from normal control. Values significantly () differ from toxic control. Values significantly () differ from toxic control. SOD unit “U” is defined as inhibition (μ moles) of NBT-reduction/min. CAT unit “U” is defined as H₂O₂ consumption/min. Gr I: normal control; Gr II: toxic control; Gr III: CA (10 mg/kg) + NaAsO₂ (10 mg/kg), Gr IV: CA (20 mg/kg) + NaAsO₂ (10 mg/kg).