Carnosic Acid, a Natural Diterpene, Attenuates Arsenic-Induced Hepatotoxicity via Reducing Oxidative Stress, MAPK Activation, and Apoptotic Cell Death Pathway

Figure 9

The effect on IκBα, NF-κB, JNK, p38, and p53 signaling in the absence (NaAsO₂) and presence of CA (NaAsO₂ + CA) in vivo in the liver of experimental mice. The relative band intensities were assessed and the normal control band was allotted a random value of 1. β-actin served as loading control. Values are expressed as mean ± SD (). ^#Values significantly () differ from normal control. Values significantly () differed from toxic control. Values significantly () differed from toxic control. Gr I: normal control; Gr II: toxic control; Gr III: CA (10 mg/kg) + NaAsO₂ (10 mg/kg), Gr IV: CA (20 mg/kg) + NaAsO₂ (10 mg/kg).