Carnosic Acid, a Natural Diterpene, Attenuates Arsenic-Induced Hepatotoxicity via Reducing Oxidative Stress, MAPK Activation, and Apoptotic Cell Death Pathway

Table 2

Effects on haematological and serum biochemical parameters in the absence (NaAsO₂) and presence of CA (CA + NaAsO₂) in mice.

Parameters	Gr I	Gr II	Gr III	Gr IV
Total erythrocyte count (×10^6/mm^3)	6.28 ± 0.42	3.22 ± 0.34^#	4.04 ± 0.25	5.19 ± 0.67
Haemoglobin (g/dl)	8.76 ± 0.72	4.89 ± 0.43^#	6.12 ± 0.48	6.88 ± 0.87
ALT (IU/I)	68.54 ± 5.81	112.98 ± 9.63^#	89.85 ± 7.62	82.17 ± 6.15
AST (IU/I)	58.12 ± 4.63	82.91 ± 7.29^#	73.62 ± 5.82	64.57 ± 5.51
CK (IU/mg protein)	10.87 ± 1.05	18.65 ± 1.24^#	14.22 ± 0.98	13.78 ± 1.33
LDH (U/l)	171.34 ± 13.42	252.67 ± 21.50^#	198.33 ± 20.12	187.54 ± 17.72

Values are expressed as mean ± SD (). ^#Values differ significantly from normal control (). Values differ significantly from NaAsO₂ control (). Values differ significantly from NaAsO₂ control (). Gr I: normal control; Gr II: toxic control; Gr III: CA (10 mg/kg) + NaAsO₂ (10 mg/kg); Gr IV: CA (20 mg/kg) + NaAsO₂ (10 mg/kg).