Research Article
Carnosic Acid, a Natural Diterpene, Attenuates Arsenic-Induced Hepatotoxicity via Reducing Oxidative Stress, MAPK Activation, and Apoptotic Cell Death Pathway
Table 3
Prediction of drug-likeness and ADME profiles of CA.
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SASA: total solvent accessible surface area; WPSA: weakly polar component of the SASA; glob: globularity descriptor; QPlogPo/w: predicted octanol/water partition coefficient; QPlogS: predicted aqueous solubility; QPlogHERG: predicted IC50 value for blockage of HERG K+ channels; QPPCaco: predicted apparent Caco-2 cell permeability; QPlogBB: predicted brain/blood partition coefficient; QPPMDCK: predicted apparent MDCK cell permeability in nm/sec; QPlogKp: predicted skin permeability; #metab: number of likely metabolic reactions; QPlogKhsa: prediction of binding to human serum albumin. |