|
| Physiological functions involving aquaporins |
|
| Generation of fluids |
| (i) Urine [150] |
| (ii) Cerebrospinal fluid [151] |
| (iii) Aqueous humor [152] |
| (iv) Sweat [21] |
| (v) Saliva [21] |
| (vi) Tears [21] |
| (vii) Bile [153] |
| (viii) Gastrointestinal juices [33] |
| (ix) Seminal fluid [154] |
| Immune response and inflammation |
| (i) Memory T-cell longevity [155] |
| (ii) Inflammatory response [156] |
| (iii) Dendritic cell maturation [157] |
| Metabolic homeostasis and energy balance |
| (i) Gluconeogenesis [158] |
| (ii) Triacylglycerol synthesis [158] |
| (iii) Ammonia detoxification via ureagenesis [159] |
| Nervous system physiology |
| (i) Multiple functions [151] |
| Other functions |
| (i) Apoptosis [160] |
| (ii) Oxidative stress [26] |
| (iii) Cell migration [161] |
| (vi) Cell volume homeostasis [162] |
| (v) Angiogenesis [163] |
|
| Pathological states involving aquaporins |
|
| (i) Cardiovascular diseases [164] |
| (ii) Renal concentration disorders [165] |
| (iii) Inflammatory diseases [156] |
| (iv) Cholestasis [153] |
| (v) Brain edema [151] |
| (vi) Cataract [162] |
| (vii) Immune system disorders (i.e., neuromyelitis optica) [166] |
| (viii) Malaria [167] |
| (ix) Obesity, diabetes, liver steatosis [158] |
| (x) Cancer [168] |
| (xi) Infertility [169] |
|
