Oxidative Medicine and Cellular Longevity / 2018 / Article / Tab 1

Review Article

Aquaporin Membrane Channels in Oxidative Stress, Cell Signaling, and Aging: Recent Advances and Research Trends

Table 1

Functional relevance of mammalian aquaporins in health and disease.

Physiological functions involving aquaporins

Generation of fluids
        (i) Urine [150]
      (ii) Cerebrospinal fluid [151]
     (iii) Aqueous humor [152]
    (iv) Sweat [21]
      (v) Saliva [21]
     (vi) Tears [21]
   (vii) Bile [153]
  (viii) Gastrointestinal juices [33]
     (ix) Seminal fluid [154]
Immune response and inflammation
        (i) Memory T-cell longevity [155]
      (ii) Inflammatory response [156]
     (iii) Dendritic cell maturation [157]
Metabolic homeostasis and energy balance
        (i) Gluconeogenesis [158]
      (ii) Triacylglycerol synthesis [158]
     (iii) Ammonia detoxification via ureagenesis [159]
Nervous system physiology
        (i) Multiple functions [151]
Other functions
        (i) Apoptosis [160]
      (ii) Oxidative stress [26]
     (iii) Cell migration [161]
     (vi) Cell volume homeostasis [162]
      (v) Angiogenesis [163]

Pathological states involving aquaporins

        (i) Cardiovascular diseases [164]
      (ii) Renal concentration disorders [165]
     (iii) Inflammatory diseases [156]
     (iv) Cholestasis [153]
      (v) Brain edema [151]
    (vi) Cataract [162]
   (vii) Immune system disorders (i.e., neuromyelitis optica) [166]
 (viii) Malaria [167]
    (ix) Obesity, diabetes, liver steatosis [158]
      (x) Cancer [168]
     (xi) Infertility [169]