Propofol Protects Hippocampal Neurons from Hypoxia-Reoxygenation Injury by Decreasing Calcineurin-Induced Calcium Overload and Activating YAP Signaling

Figure 6

Calcineurin did not affect YAP activation in hippocampal neurons. HT-22 cells were pretreated with cyclosporin (1 μmol/l for 2 hr) or transfected with different calcineurin shRNAs for 48 hr, then starved and treated with propofol (15 μmol/l for 4 hr). Cell lysates were analyzed by Western blot to detect expression of YAP and pYAP.