Antiulcer Activity and Potential Mechanism of Action of the Leaves of Spondias mombin L.

Figure 12

Effect of ethanolic extract of the leaves of Spondias mombin (SmEE) on lipopolysaccharide- (LPS-) induce oxide nitric (NO) production in macrophages. Adherent cells (1 × 10⁶) were incubated for 24 h with extract and LPS (5 mg/mL). Cells incubated just with LPS were used as a positive control and cell in culture medium (DMEM) as a control group. Nitrite concentrations in the medium were determined using Griess reagent. The results are expressed as the mean ± SEM for three different experiments performed in triplicate. One-way ANOVA, followed by Dunnett’s multiple comparisons test; and versus LPS control.