Antiulcer Activity and Potential Mechanism of Action of the Leaves of Spondias mombin L.

Table 4

Effect of the oral pretreatment with ethanolic extract of the leaves of Spondias mombin (SmEE) on gastric lesions induced by absolute ethanol in rats.

Pretreatment	Absolute ethanol-induced ulcer
	Lesion area (mm^2)	LPO (nmol of MDA/mg protein)	−SH groups (nmol/mg protein)
Injured control (LC)	229.80 ± 11.00	0.29 ± 0.02	1.80 ± 0.32
Lansoprazole (30 mg/kg)	24.67 ± 3.50	0.13 ± 0.02	4.72 ± 0.56
SmEE (50 mg/kg)	175.00 ± 17.78	0.18 ± 0.00	4.66 ± 0.42
SmEE (100 mg/kg)	22.20 ± 3.22	0.18 ± 0.01	4.75 ± 0.85
SmEE (200 mg/kg)	22.35 ± 2.14	0.21 ± 0.01	4.49 ± 0.36

LPO: lipid peroxidation; −SH groups: nonprotein sulfhydryl groups. The results are expressed as the mean ± SEM (n = 5–7/group). ANOVA followed Dunnett’s multiple comparisons test; , , and .