Antiulcer Activity and Potential Mechanism of Action of the Leaves of Spondias mombin L.

Table 7

Effect of oral administration of ethanolic extract of the leaves of Spondias mombin (SmEE) on gastric lesions induced by ethanol in Wistar rats pretreated with Nω-nitro-L-arginine methyl ester (L-NAME, 70 mg/kg) or N-ethylmaleimide (NEM, 10 mg/kg).

Pretreatment	Treatment (p.o.)	Dose (mg/kg)	Lesion area (mm^2)	Inhibition (%)
0.9% NaCl (i.p.)	LC	—	56.68 ± 2.83	—
	Carbenoxolone	100	5.40 ± 0.47	90.47%
	SmEE	100	32.80 ± 2.38	42.13%
	L-Arginine	200	320.30 ± 101.5	+465.10%
L-NAME (i.p.)	LC	—	120.80 ± 3.33	—
	Carbenoxolone	100	24.22 ± 1.01	79.95%
	SmEE	100	47.00 ± 2.59	61.09%
	L-Arginine	200	74.44 ± 12.80	38.38%
NEM (i.p.)	LC	—	155.30 ± 9.8	—
	Carbenoxolone	100	44.90 ± 3.15	70.51%
	SmEE	100	70.60 ± 3.93	54.54%

The results are expressed as the mean ± SEM (n=6-7). LC: injured control group. One-way ANOVA, followed by Dunnett’s multiple comparisons test; .