Oxidative-Nitrative Stress and Poly (ADP-Ribose) Polymerase Activation 3 Years after Pregnancy

Figure 2

Pre- and postload values of ON stress and PARP activation markers in the study groups. (a) Plasma total peroxide. In the fasting state, all previously pregnant groups had significantly increased plasma total peroxide level compared to men and nulliparas. The two-hour postload value of this parameter was similar to that seen in the fasting state. The between-group differences in postload levels were also similar to those found in the fasting state; however, only the DGDM and IGDM groups were significantly different from nulliparas. (b) Protein tyrosine nitration in circulating mononuclear cells. There was no significant between-group difference of protein nitration neither in the fasting nor in the postload state. On the other hand, the postload values were significantly higher compared to the fasting state. (c) Protein PARylation in circulating mononuclear cells. Similar changes can be observed in the case of protein PARylation that was observed regarding protein nitration. In the boxplot, the central line shows the median; the box represents the interquartile range; and the whiskers mark the minimum and maximum values. Two-way repeated measures ANOVA, Tukey post hoc test. ###: versus MALE; ł: versus NULL; łł: versus NULL; łłł: versus NULL; a: preload versus postload.

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