Distribution of Paraoxonase-1 (PON-1) and Lipoprotein Phospholipase A2 (Lp-PLA2) across Lipoprotein Subclasses in Subjects with Type 2 Diabetes
Table 4
Pearson’s correlation coefficients of the relationship of arylesterase, lactonase, or Lp-PLA2 with serum lipids or lipoprotein subfractions in controls and in type 2 DM subjects.
Lipoproteins
Controls
Type 2 diabetes
Arylesterase
Lactonase
Lp-PLA2
Arylesterase
Lactonase
Lp-PLA2 r
Total cholesterol
0.172
0.201
0.265
0.315
0.302
0.411
HDL-C
0.404
0.159
−0.100
0.464
0.168
−0.060
LDL-C
0.174
0.154
0.232
0.063
0.233
0.388
Triglycerides
−0.169
−0.009
0.183
−0.246
0.212
0.189
Large HDL-C (%)
0.192
0.011
0.108
−0.046
−0.064
−0.141
Medium HDL-C (%)
−0.094
−0.019
−0.096
0.013
−0.024
−0.021
Small HDL-C (%)
−0.195
0.002
−0.045
0.073
0.100
0.151
Large HDL-C (mg/dL)
0.257
−0.068
0.077
0.124
0.067
−0.134
Medium HDL-C (mg/dL)
0.223
0.128
−0.011
0.245
0.187
−0.124
Small HDL-C (mg/dL)
−0.163
0.108
0.007
0.226
0.215
−0.046
Large LDL-C
−0.041
0.146
0.312
0.143
0.113
0.104
Small LDL-C
−0.196
−0.044
0.117
0.223
0.263
0.314
Mean LDL particle size
0.244
0.074
−0.059
0.079
−0.191
−0.280
Large IDL-C
0.098
0.097
0.051
0.285
0.400
0.314
Medium IDL-C
0.037
0.097
−0.004
0.367
0.314
0.205
Small IDL-C
0.274
0.188
−0.018
0.309
0.077
0.056
VLDL-C
−0.008
0.005
−0.086
0.288
0.338
0.283
;; significant partial correlation coefficients (covariates: age, sex, smoking, hypertension, and BMI) are highlighted in italics. HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; VLDL: very low-density lipoprotein cholesterol; IDL-C: intermediate-density lipoprotein cholesterol. Lactonase was measured in 152/202 controls; Lp-PLA2 was measured in 111/202 controls.
