R(+)-Thioctic Acid Effects on Oxidative Stress and Peripheral Neuropathy in Type II Diabetic Patients: Preliminary Results by Electron Paramagnetic Resonance and Electroneurography

Figure 1

Scheme of the experimental protocol. Experimental timeline of the protocol adopted to monitor the effects of R(+)-thioctic acid supplementation on glucose levels, hematological profile, ROS production rate, oxidative damage, and ENG in type II diabetic neuropathic patients. The three monitored periods, study session (120 days: T0–T6), wash out (60 days: T6-T7), control session (30 days: T7-T8), are indicated (a). Sketch of the experimental protocol adopted to measure the EPR determined ROS production rate. The stacked plots of the EPR spectra recorded at the baseline (T0), 60 days (T4, yellow spectra), and 120 days (T6) are displayed. The significant differences and are indicated (b).

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