Oxidative Medicine and Cellular Longevity

Review Article

Anticancer Properties of Graviola (Annona muricata): A Comprehensive Mechanistic Review

Table 2

AGEs of A. muricata reported to have anticancer activities. Structures were drawn using ChemDraw, Arial, point 20.


Compound names	Structure	Molecular formula	MWT (g/mol)	Cancer cell lines tested on

Annocatacin A		C₃₅H₆₂O₆	578.88	Hepatic (Hep G2 and Hep 2,2,15) cancer [80]
Annocatacin B		C₃₅H₆₂O₆	578.88	Hepatic (Hep G2 and Hep 2,2,15) cancer [80]
Annocatalin		C₃₅H₆₄O₇	596.89	Hepatic (Hep G2 and Hep 2,2,15) cancer [81]
Annohexocin		C₃₅H₆₄O₉	628.888	Breast (MCF-7), prostate (PC-3), colorectal (HT-29), lung (A549), renal (A498) and pancreatic (PACA-2) cancers [34]
Annomuricin A		C₃₅H₆₄O₈	612.889	Breast (MCF-7), colorectal (HT-29), lung (A549) [17], and leukemic (U-937) [46] cancers
Annomuricin B		C₃₅H₆₄O₈	612.889	Breast (MCF-7), colorectal (HT-29), and lung (A549) cancers [17]
Annomuricin C		C₃₅H₆₄O₈	612.889	Breast (MCF-7), colorectal (HT-29), and lung (A549) cancers [86]
Annomuricin E		C₃₅H₆₄O₈	612.889	Breast (MCF-7), prostate (PC-3), lung (A549), renal (A498), pancreatic (PACA) [16], and colorectal (HT-29) cancers [16, 25]
Annomutacin		C₃₇H₆₈O₇	624.944	Breast cancer (MCF-7), colorectal (HT-29), and lung cancers (A549) [43]
Annonacin		C₃₅H₆₄O₇	596.89
Annonacin A		C₃₅H₆₄O₇	596.89	Leukemia (U-937) [46]
Annonacinone		C₃₅H₆₂O₇	594.874	Oral cancer (KB) [35]
Annopentocin A		C₃₅H₆₄O₈	612.889	Breast (MCF-7), prostate (PC-3), colorectal (HT-29), lung (A549), renal (A498), and pancreatic (PACA-2) cancers [32]
Annopentocin B		C₃₅H₆₄O₈	612.889	Breast (MCF-7), prostate (PC-3), colorectal (HT-29), lung (A549), renal (A498), and pancreatic (PACA-2) cancers [32]
Annopentocin C		C₃₅H₆₄O₈	612.889	Breast (MCF-7), prostate (PC-3), colorectal (HT-29), lung (A549), renal (A498), and pancreatic (PACA-2) cancers [32]
Arianacin		C₃₅H₆₄O₇	596.89	Breast (MCF-7), colorectal (HT-29), and lung (A549) cancers [85]
Corossolin		C₃₅H₆₄O₆	580.891	Hepatic (Hep G2 and Hep 2,2,15) [82] and oral (KB) cancers [35]
Corossolone		C₃₅H₆₂O₆	578.875	Hepatic cancer (Hep G2 and Hep 2,2,15) [82] and oral (KB) cancers [35, 83]
Gigantetrocin		C₃₅H₆₄O₇	596.89	Breast (MCF-7), colorectal (HT-29), and lung (A549) cancers [49]
Gigantetrocin A		C₃₅H₆₄O₇	596.89	Breast (MCF-7), colorectal (HT-29), and lung (A549) cancers [50]
Gigantetrocin B		C₃₅H₆₄O₇	596.89	Breast (MCF-7), colorectal (HT-29), and lung (A549) cancers [17, 50]
Goniothalamicin		C₃₅H₆₄O₇	596.89	Breast (MCF-7), colorectal (HT-29), and lung (A549) cancers [49]
Isoannonacin		C₃₅H₆₄O₇	596.89	Breast (MCF-7), colorectal (HT-29), and lung (A549) cancers [48]
Isoannonacin-10-one		C₃₅H₆₂O₇	594.874	Breast (MCF-7), colorectal (HT-29), and lung (A549) cancers [49]
Javoricin		C₃₅H₆₄O₇	596.89	Breast (MCF-7), colorectal (HT-29), and lung (A549) cancers [85]
Longifolicin		C₃₅H₆₄O₆	580.891	Hepatic (Hep G2 and Hep 2,2,15) cancer [82]
Muricapentocin		C₃₅H₆₄O₈	612.889	Breast (MCF-7), prostate (PC-3), colorectal (HT-29), lung cancer (A549), renal (A498), and pancreatic (PACA) cancers [16]
Muricatacin		C₁₇H₃₂O₃	284.44	Breast (MCF-7), colorectal (HT-29), and lung (A549) cancers [48]
Muricatetrocin A		C₃₅H₆₄O₇	596.89	Breast (MCF-7), colorectal (HT-29), and lung (A549) cancers [17, 50]
Muricatetrocin B		C₃₅H₆₄O₇	596.89	Breast (MCF-7), colorectal (HT-29), and lung (A549) cancers [17, 50]
Muricatocin A		C₃₅H₆₄O₈	612.889	Breast (MCF-7), colorectal (HT-29) and lung (A549) cancers [44]
Muricatocin B		C₃₅H₆₄O₈	612.889	Breast (MCF-7), colorectal (HT-29), and lung (A549) cancers [44]
Muricatocin C		C₃₅H₆₄O₈	612.889	Breast (MCF-7), colorectal (HT-29), and lung (A549) cancers [86]
Muricenin				Prostate (PC-3) cancer [30]
Muricin A		C₃₅H₆₄O₇	596.878	Hepatic (Hep G2 and Hep 2,2,15) cancer [82]
Muricin B		C₃₅H₆₄O₇	596.878	Hepatic (Hep G2 and Hep 2,2,15) cancer [82]
Muricin C		C₃₅H₆₄O₇	596.878	Hepatic (Hep G2 and Hep 2,2,15) cancer [82]
Muricin D		C₃₃H₆₀O₇	568.836	Hepatic (Hep G2 and Hep 2,2,15) cancer [82]
Muricin E				Hepatic (Hep G2 and Hep 2,2,15) cancer [82]
Muricin F		C₃₅H₆₂O₇	594.874	Hepatic (Hep G2 and Hep 2,2,15) cancer [82]
Muricin G				Hepatic (Hep G2 and Hep 2,2,15) cancer [82]
Muricin H		C₃₅H₆₄O₆	580.891	Hepatic (Hep G2 and Hep 2,2,15) cancer [81]
Muricin I		C₃₇H₆₆O₆	606.929	Hepatic (Hep G2 and Hep 2,2,15) cancer [81]
Muricin J		C₂₂H₃₈O₇	414.2618	Prostate (PC-3) cancer [29]
Muricin K		C₂₄H₄₂O₇	442.2931	Prostate (PC-3) cancer [29]
Muricin L		C₂₄H₄₂O₇	442.2931	Prostate (PC-3) cancer [29]
Muricin M		C₂₄H₄₂O₇	442.2931	Prostate (PC-3) cancer [30]
Muricin N		C₂₂H₃₈O₇	414.2618	Prostate (PC-3) cancer [30]
Muricoreacin		C₃₅H₆₄O₉	628.4550	Breast (MCF-7), prostate (PC-3), colorectal (HT-29), lung cancer (A549), renal cancer (A498), and pancreatic (PACA-2) cancers [47]
Murihexocin A		C₃₅H₆₄O₉	628.888	Breast (MCF-7), prostate (PC-3), colorectal (HT-29), lung (A549), renal (A498), and pancreatic (PACA-2) cancers [15]
Murihexocin B		C₃₅H₆₄O₉	628.4550	Breast (MCF-7), prostate (PC-3), colorectal (HT-29), lung (A549), renal (A498), and pancreatic (PACA-2) cancers [15]
Murihexocin C		C₃₁H₅₆O₉	572.3924	Breast (MCF-7), prostate (PC-3), colorectal (HT-29), lung cancer (A549), renal cancer (A498), and pancreatic (PACA-2) cancers [47]
Murisolin		C₃₅H₆₃NO₆	593.4655	Oral (KB) cancer [35]
Solamin		C₃₅H₆₄O₅	564.892	Oral (KB) cancer [35]
Vinblastine		C₄₆H₅₈N₄O₉	810.989	Oral (KB) cancer [35]
cis-Annomontacin		C₃₇H₆₈O₇	624.4965	Hepatic (Hep G2 and Hep 2,2,15) cancer [88]
cis-Annonacin		C₃₅H₆₄O₇	596.88	Breast (MCF-7), colorectal (HT-29), and lung (A549) cancers [85]
cis-Annonacin-10-one		C₃₅H₆₂O₇	594.874	Breast (MCF-7), colorectal (HT-29), and lung (A549) cancers [85]
cis-Corossolone		C₃₅H₆₂O₆	578.875	Hepatic (Hep G2 and Hep 2,2,15) cancer [81]
cis-Goniothalamicin		C₃₅H₆₄O₇	596.89	Breast (MCF-7), colorectal (HT-29), and lung (A549) cancers [85]