N-Acetylcysteine Reduces ROS-Mediated Oxidative DNA Damage and PI3K/Akt Pathway Activation Induced by Helicobacter pylori Infection

Figure 1

H. pylori induces DNA damage and increases the ROS level in gastric epithelial cells (GES-1) cells, but pretreatment with NAC protects cells from oxidative damage. (a) At 6 h of culture, DNA damage was examined using comet formation assay, scale . (b) ROS levels were determined by measuring the level of fluorescent DCF; compared to the control group. (c) Comet formation was quantitatively assessed according to the relative tail moment at 6 h of culture; .

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