Oxidative Medicine and Cellular Longevity / 2018 / Article / Fig 2

Research Article

Cell Size Influences the Reproductive Potential and Total Lifespan of the Saccharomyces cerevisiae Yeast as Revealed by the Analysis of Polyploid Strains

Figure 2

The spontaneous mutagenesis level in yeast cells depends on their ploidy. The changes in spontaneous mutagenesis levels at CAN1 and URA3 loci in cells of different ploidy (1n, 2n, 3n, and 4n) in the BY474X background. Spontaneous mutagenesis was measured using a forward mutation assay. Forward mutations leading to canavanine (CanR) or 5-fluoroorotic acid (5-FOAR) resistance are median values from at least 30 independent cultures of each strain in three separate experiments. The differences of mutation frequencies between investigated strains were statistically significant ().

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