Apoptosis and Mobilization of Lymphocytes to Cardiac Tissue Is Associated with Myocardial Infarction in a Reperfused Porcine Model and Infarct Size in Post-PCI Patients

Figure 4

Lymphocyte and T cell dynamics STEMI patients. Total lymphocyte, lymphocyte apoptosis (Annexin V+ cells), and T cell subset count (cells/μl) from blood of STEMI patients at different time points: after MI and before reperfusion (pre-PCI) and after MI and after reperfusion (24 h, 96 h, and 30 d post-PCI). A significant drop of lymphocytes, T cell (CD3⁺), CD4, CD8, and Th1 (CD4⁺CXCR3⁺) 24 h post-PCI was observed in STEMI patients. While B cells (CD19⁺) and Th2 (CD4⁺CCR4+) did not change. Treg (CD4⁺CD25⁺FOXP3⁺) increased after one month. Values are expressed as mean ± SD. or versus pre-PCI. PCI: percutaneous coronary intervention; SD: standard deviation; STEMI: ST-segment myocardial infarction; Treg: T regulatory cells.

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