Protective Role of Carbonic Anhydrases III and VII in Cellular Defense Mechanisms upon Redox Unbalance

Figure 3

Chemical environment of CA III and VII reactive cysteines. (a) S-glutathionylated Cys183 of CA III showing two alternative conformations. (b) S-glutathionylated Cys188 of CA III surrounded by Arg189, Asp190, Lys213, and Glu214 which affect its pKa. (c) Model of Cys183 in CA VII structure adjacent to His154. (d) Model of Cys217 in CA VII structure showing the nearby acidic and basic residues.

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(b)

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