The Isoquinoline Alkaloid Dauricine Targets Multiple Molecular Pathways to Ameliorate Alzheimer-Like Pathological Changes <i>In Vitro</i>

<div>DAU ameliorated tau pathology via PP2A and p35/25 in both N2a/APP cells and HEK293/Tau cells. Phosphorylation of GSK3 and PP2A and levels of p35/25 and CDK5 in N2a/APP cells (a, b) and HEK293/Tau cells (c, d) as determined by Western blot analysis. <i>β</i>-Actin was used as a loading control. <span class="nowrap"><svg height="8.8423pt" id="M37" style="vertical-align:-0.2064009pt" version="1.1" viewbox="-0.0498162 -8.6359 32.2343 8.8423" width="32.2343pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M822 650H589L583 622C660 617 677 607 674 561C672 534 664 481 647 390L600 137H596L273 650H126L120 622C176 620 194 615 207 594C221 571 225 557 214 504L161 257C141 166 129 112 121 85C108 42 83 30 29 28L23 0H260L266 28C193 33 173 42 176 89C178 122 186 172 202 255L256 527H259L583 -8H612L690 390C708 481 720 535 728 558C744 603 756 619 816 622L822 650Z" id="g113-79"></path></g><g transform="matrix(.013,0,0,-0.013,14.542,0)"><path d="M535 323V373H52V323H535ZM535 138V188H52V138H535Z" 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109 27V0H384Z" id="g113-50"></path></g></svg> compared to untreated HEK293/Tau cells.</div>

Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: The Isoquinoline Alkaloid Dauricine Targets Multiple Molecular Pathways to Ameliorate Alzheimer-Like Pathological Changes <i>In Vitro</i> 

Oxidative Medicine and Cellular Longevity

The Isoquinoline Alkaloid Dauricine Targets Multiple Molecular Pathways to Ameliorate Alzheimer-Like Pathological Changes In Vitro

Figure 4