The Isoquinoline Alkaloid Dauricine Targets Multiple Molecular Pathways to Ameliorate Alzheimer-Like Pathological Changes In Vitro

Figure 5

DAU caused differential expression of proteins in N2a/APP cells. DAU caused differential expression of 49 proteins including oxidative stress-associated proteins, endoplasmic reticulum (ER) stress-associated proteins, metabolism-associated proteins, cytoskeleton-associated proteins, molecular chaperones-associated proteins, signaling-associated proteins, and others. Protein expression was significantly altered in any four comparison pairs (N2a/APP versus N2a/WT, 1.25 μM DAU versus N2a/APP, 5 μM DAU versus N2a/APP, or 20 μM DAU versus N2a/APP).